Many Americans participate in office pools where they fill out the bracket to predict which team wins each game. There's lots of math one can use for your bracket. But here is my advice: Pick the higher seeded teams to beat the lower seeded teams. Every time. There will be upsets but you can't predict where they will be so you have the best chances predicting none of them.
The most likely seeds to make the final four are two number 1's, a number 2 and a number 3, 3 times in the last 27 years. So why follow my advice which predicts four number 1's. Because there are 12 ways to get 11 2 3 and only one way to get 1 1 1 1 and you have to pick a specific combination when you fill out your bracket. The four first seeds all went to the final four only once in the last 27 years but given there's only one such combination that makes it more likely than any other possibility.
May the madness begin.