I prefer to use the Martian rule. Suppose we find a Martian civilization at about the same level of scientific progress that we have. If they have a concept the same or similar to one of ours than that concept would be natural, having developed through multiple independent sources.
Of course we don't have a Martian civilization to compare ourselves with so we have to use our imagination. I firmly believe the Martians would have developed the P versus NP question (or something very similar, assuming they haven't already solved it) making the question very natural. On the other hand I suspect the Martians might not have developed a class like LWPP. Other classes like UP are less clear, I guess it depends whether the Martians like their solutions unique.
Applying the Martian rule to Gasarch's post, WS1S is probably more natural than regular languages without squaring that equal Σ*. At least my Martians would say that.