As we celebrate our successes in computational complexity here's a sobering fact: We have had no new non-relativizing techniques in the last 25 years.
A little background: In 1975, a few years after Cook established the P v NP problem, Baker, Gill and Solovay created two sets A and B such that every NP machine that could ask questions about A could be simulated by a P machine that could ask questions to A and there is some language accepted by an NP machine that could ask questions to B that cannot be solved by a P machine that could ask questions to B. In other words PA = NPA but PB ≠ NPB.
All the known proof techniques at the time relativized, i.e., if you proved two classes were the same or different, they would be the same of different relative to any set. BGS implied that these techniques could not settle the P v NP problem.
In the 80's and 90's we got very good at creating these relativized worlds and, with a couple of exceptions, we created relativized worlds that make nearly all the open questions of complexity classes between P and PSPACE both true and false.
There were some results in the that were non-relativizing for technical uninteresting reasons. In the late 80s/early 90s we had some progress, results like NP having zero-knowledge proofs, co-NP (and later PSPACE) having interactive proofs and NEXP having (exponential-sized) probabilistically checkable proofs, despite relativized worlds making those statements false. But then it stopped. We had a few more nonrelativizing results but those just used the results above, not any new techniques.
In 1994 I wrote on survey on what relativization meant post-interactive proofs, still mostly up to date. We have seen new barriers put up such as natural proofs and algebrization, but until we can at least get past traditional relativization we just cannot make much more progress with complexity classes.